Michael E. Hall

This study investigates how resistance training volume affects skeletal muscle adaptations and inter-individual response variation using a within-participant design, finding detectable benefits for hypertrophy but not strength, and limited evidence of true inter-individual differences.

The paper identifies genetic and phenotypic correlates of mosaic loss of chromosome Y in blood using whole genome sequencing data from the TOPMed program.

Over 400 million variants, 97% below 1% frequency, emerge from deep whole-genome sequencing of 53,831 diverse TOPMed participants; TOPMed haplotypes enable imputation down to ~0.01% frequency.