The phylogenetic functional conservation of Drosophila Seven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, in Drosophila eye development
Robert E. Van Sciver, Yajun Cao, Amy Tang
This study identifies functionally conserved roles of Drosophila SINA and human SIAH1/2 in RAS/EGFR pathway regulation, showing their efficacy in blocking neuronal cell fate determination in Drosophila.
bioRxiv · Apr 28, 2020 · PreprintDevelopmental Biology