Twin pair analysis uncovers novel links between DNA methylation, mitochondrial DNA quantity and obesity
Aino Heikkinen, Vivienne F. C. Esser, Seung Hyuk Lee, Sara Lundgren, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per‐Henrik Groop, Sini Heinonen, Sergio Villicaña, Jordana T. Bell, Alice Maguolo, Emma Nilsson, Charlotte Ling, Allan Arthur Vaag, , Miina Ollikainen
The paper identifies a locus, SH3BP4, where DNA methylation correlates with mtDNAq and obesity-related traits in adipose tissue, suggesting potential causal relationships.
Nature Communications · May 12, 2025Peer-reviewedGenetic & Genomic Medicine