Aino Heikkinen

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

This study explores proteomic and epigenetic aging clocks as biomarkers for Alzheimer's disease phenotypes, finding proteomic clocks improve explained variance in cognitive and biomarker measures by up to 18%.

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

The paper identifies a locus, SH3BP4, where DNA methylation correlates with mtDNAq and obesity-related traits in adipose tissue, suggesting potential causal relationships.

The paper identifies 40 multi-omic factors associated with epigenetic age acceleration in young twins, with six remaining significant after accounting for genetic effects, and finds some associations persist across generations in older twins.

This study finds that early childbearing, numerous pregnancies, and nulliparity are associated with accelerated aging and increased mortality risk in Finnish twin women.

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

This study identifies DNA methylation sites associated with pubertal timing and development in young adults using twin data and examines their genetic and environmental influences.

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

The paper examines nc886 methylation across populations and tissues, finding stable levels except in specific tissues and some discordance in dizygotic twins.