Jaakko A. Kaprio

The paper introduces the Proteomic Sex Index (PSI), a continuous measure of plasma proteome alignment with chromosomal sex, showing its association with health and disease traits.

The paper develops BEAC, an epigenetic clock for birds, validated across multiple species and showing strong predictive performance for chronological age.

This study investigates the association between genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality using a 17-year cohort, finding that genetic factors and lifestyle factors like smoking and sex independently influence mortality risk.

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

This study conducts an epigenome-wide association study (EWAS) meta-analysis of wellbeing using DNA methylation data, finding no significant methylation sites but suggesting the need for larger studies.

This study explores proteomic and epigenetic aging clocks as biomarkers for Alzheimer's disease phenotypes, finding proteomic clocks improve explained variance in cognitive and biomarker measures by up to 18%.

The paper evaluates a polygenic score for handgrip strength and its interaction with physical activity across twin cohorts, finding a significant genetic association and effect modification by physical activity.

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study examines how genetic risk scores for alcohol use behaviors change over time across multiple cohorts, finding varying associations with drinking patterns and trajectories.

The paper integrates GWAS meta-analysis with human brain cell mapping to identify genetic loci and cell types involved in tinnitus, implicating the amygdala and midbrain.

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

This study identifies 1,242 novel genetic variants and 31 novel genes associated with frailty through genome-wide association and proteomics integration.

This study identifies 93 genetic loci associated with alcohol-related diseases using FinnGen data and shows polygenic risk scores can stratify risk for these diseases and related outcomes.

The paper develops a proteomic signature (HPS) to predict healthspan, showing it predicts mortality and age-related diseases better than other biological age measures.

The paper estimates heritability for 2,321 plasma proteins using twin data and finds that SNP-based heritability accounts for only half of the total genetic effects.

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

The paper identifies a locus, SH3BP4, where DNA methylation correlates with mtDNAq and obesity-related traits in adipose tissue, suggesting potential causal relationships.

The paper identifies 40 multi-omic factors associated with epigenetic age acceleration in young twins, with six remaining significant after accounting for genetic effects, and finds some associations persist across generations in older twins.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

The paper compares transcriptomic and metabolomic data from monozygotic and dizygotic twins to identify molecular biomarkers of twinning, finding no replicable transcript-level differences but highlighting potential pathways.

The paper identifies DNA methylation markers associated with breast cancer risk in twin pairs, showing most are independent of genetic effects and linked to environmental factors.

This study conducts a genome-wide meta-analysis across three biobanks to identify new genetic loci associated with lumbar disc herniation, expanding the known genetic landscape.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

This study finds that early childbearing, numerous pregnancies, and nulliparity are associated with accelerated aging and increased mortality risk in Finnish twin women.

This study identifies 14 plasma proteins associated with the p-factor in young adults using proteomics.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

The paper develops a method to infer compound heterozygosity from exome sequencing data, achieving high accuracy in phasing rare variants for recessive disease diagnosis.

This study identifies DNA methylation sites associated with pubertal timing and development in young adults using twin data and examines their genetic and environmental influences.

This study identifies proteins and genes associated with BMI and its changes in twins, showing shared genetic and environmental factors across proteome, transcriptome, and metabolome layers.