NONO as a Sensor of Intracellular Oxidation: Relevance to Neuroblastoma Cell Death
Sofya S. Pogodaeva, Olga O. Miletina, Н. В. Антипова, Alexander Albertovich Shtil, Oleg A. Kuchur
This study identifies NONO as a redox sensor in MYCN-amplified neuroblastoma cells, showing that its downregulation by oxidative stress synergizes with auranofin to induce cell death.
bioRxiv · Oct 30, 2025 · PreprintCancer Biology