Quantitative 3D cytoarchitecture of human brain organoids using light-sheet microscopy
Omkar Suhas Vinchure, Amy Vivien Job, Hugo Alonso-Olivares, Fowzan Sami Alkuraya, Elke Gabriel, Jay Gopalakrishnan
The paper introduces LUCID-org, a method for 3D imaging and analysis of human brain organoids, revealing cytoarchitectural defects in CENPJ-mutated microcephaly organoids.
bioRxiv · Mar 20, 2026 · PreprintDevelopmental Biology