The paper introduces LUCID-org, a method for 3D imaging and analysis of human brain organoids, revealing cytoarchitectural defects in CENPJ-mutated microcephaly organoids.

bioRxiv · Mar 20, 2026 · PreprintDevelopmental Biology

CCB79 is a primate-specific cilium initiation factor essential to maintain neural progenitor diversity in developing brain tissue.

Dhanasekaran Rathinam, Vaibhav Jadhav, Seema Wasim, Dina Elkahwagy, Nazlican Altinisik, Enes Cicek, Tejas Borkar, Aruljothi Mariappan, Omkar Suhas Vinchure, Nadine Poempner, Ziliang Zhao, Samhan M. Alsolami, Mo Li, Johannes Ptok, Christian Eggeling, , Jay Gopalakrishnan

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

bioRxiv · Aug 1, 2025 · PreprintNeuroscience

Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs

Ting Xie, Adi Danieli‐Mackay, Mariachiara Buccarelli, Mariano Barbieri, Ioanna Papadionysiou, Quintino Giorgio D’Alessandris, Nadine Übelmesser, Omkar Suhas Vinchure, Liverana Lauretti, Giorgio Fotia, Xiaotao Wang, Lucia Ricci‐Vitiani, Jay Gopalakrishnan, Roberto Pallini M. D, Argyris Papantonis

The paper maps structural variants and neoloops in glioblastoma stem cells to show how they sustain tumor-specific transcriptional programs and identify patient-specific vulnerabilities.

bioRxiv · Apr 20, 2023 · PreprintGenomics