Jay Gopalakrishnan

Quantitative 3D cytoarchitecture of human brain organoids using light-sheet microscopy

The paper introduces LUCID-org, a method for 3D imaging and analysis of human brain organoids, revealing cytoarchitectural defects in CENPJ-mutated microcephaly organoids.

Oxidized MIF is an Alzheimer's Disease drug target relaying external risk factors to tau pathology

The paper identifies oxidized MIF as a drug target that links HSV-1 infection and external stressors to tau pathology in Alzheimer's disease.

CCB79 is a primate-specific cilium initiation factor essential to maintain neural progenitor diversity in developing brain tissue.

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs

The paper maps structural variants and neoloops in glioblastoma stem cells to show how they sustain tumor-specific transcriptional programs and identify patient-specific vulnerabilities.

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

This study shows that inhibiting centrosome clustering reduces cyst growth and improves kidney function in ADPKD by activating p53-mediated apoptosis.

Human brain organoids assemble functionally integrated bilateral optic vesicles

This study shows human brain organoids can form bilateral optic vesicles with cellular diversity and functionality, including light-responsive photoreceptors and neuronal networks.

RRP7A links primary microcephaly to radial glial cells and dysfunction of ribosomal biogenesis, neurogenesis and ciliary resorption

This study identifies a mutation in RRP7A linked to primary microcephaly, showing its role in neurogenesis, ribosomal biogenesis, and ciliary resorption in neural stem cells.