Cell BiologyCommunications BiologyPeer-reviewed
A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans
Benoît Vanderperre, Amitha Muraleedharan, Marie‐France Dorion…·Edward A. Fon
This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.
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