Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28 gene
Elena Igorevna Stepchenkova, Anna S. Zhuk, Jian Cui, Elena Tarakhovskaya, Stephanie R. Barbari, Polina V. Shcherbakova, Dmitrii E. Polev, Roman Fedorov, Eugenia Poliakov, Igor B. Rogozin, Artem G. Lada, Youri I. Pavlov
The paper shows that yeast strains lacking the active N-terminal half of DNA polymerase ε adapt through positive selection of mutations in CDC28, improving growth and reducing sensitivity to replication inhibitors.
Genetics · Apr 12, 2021Peer-reviewedGenetics