GeneticsGeneticsPeer-reviewed
Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28 gene
Elena Igorevna Stepchenkova, Anna S. Zhuk, Jian Cui…·Youri I. Pavlov
The paper shows that yeast strains lacking the active N-terminal half of DNA polymerase ε adapt through positive selection of mutations in CDC28, improving growth and reducing sensitivity to replication inhibitors.
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