Andrea Castro

The paper identifies epistatic interactions between cancer driver mutations and allele-specific copy number variations in tumors, showing their impact on patient survival.

The paper identifies a relationship between protein structure and glycan structure, introducing a glycoimpact matrix to predict glycosylation patterns and validate it through disease variants and engineered antibodies.

The paper shows that neopeptide immunogenicity is influenced by the subcellular location of their parent proteins, improving predictions of vaccine and immunotherapy responses.

The paper examines how the N501Y mutation in SARS-CoV-2 affects MHC-II presentation, suggesting it may reduce immune response and contribute to immune escape.