Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy
Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero, Rong Grace Zhai
This study shows that reducing spermine synthase enhances autophagy and reduces Tau accumulation in Tauopathy models.
bioRxiv · Mar 17, 2023 · PreprintNeuroscience