Chong V. Li

The paper develops COSCO to map neuronal connectivity in cerebral organoids and shows self-organizing network motifs and disease-related topological changes.

The paper uses CRISPR and single-cell transcriptomics to screen ASD risk genes in brain organoids, identifying developmental defects and regulatory modules linked to autism.

The paper presents long-read assemblies of 43 diverse human Y chromosomes, revealing extensive structural complexity and variation across 180,000 years of evolution.

This study measures RNA secondary structures in Plasmodium falciparum during asexual development, finding that ~71% of structured RNAs are protein-coding and that structural content correlates with translation efficiency.

The paper identifies 4E-BP mRNA targets in Drosophila and mammals using hyperTRIBE, showing they have specific motifs and are enriched in translation-related pathways.

This study shows that knocking down WISP2/CCN5 promotes breast cancer cell proliferation by upregulating Skp2 and downregulating p27Kip1.

This study identifies dme-miR-1002 as a microRNA that enhances stress resistance by promoting alternative splicing of NMNAT pre-mRNA to the protective RB variant in Drosophila.