Dru Myerscough

The Emergence of Novel Versus Known Three-Dimensional Structures from Random Sequences.

This study shows that random sequences repeated in tandem are more likely to fold into stable structures than fully random sequences, with some structures being novel and experimentally confirmed.

Predicting optimal growth temperatures of bacteria using learned structural information from a single protein

This paper develops ROSEATE, a model predicting bacterial optimal growth temperatures using protein structural features from a single gene, showing high accuracy and phylogenetic generalizability.

Using domain insertion to create sulfite reductases that present chemical-dependent activities

The paper demonstrates how domain insertion can create sulfite reductases with ligand-dependent activity, showing enhanced cellular activity in response to an endocrine disruptor.

Synonymous mutations in AAV Rep enhance genome packaging in a library selection

The paper identifies synonymous mutations in the AAV Rep gene that enhance genome packaging efficiency by affecting Rep-DNA interactions.

Determinants of multiheme cytochrome extracellular electron transfer uncovered by systematic peptide insertion

This study identifies key residues in MtrA that influence extracellular electron transfer by systematically inserting peptides and analyzing their impact on respiration efficiency.