Rian C. Kormos

This study shows that random sequences repeated in tandem are more likely to fold into stable structures than fully random sequences, with some structures being novel and experimentally confirmed.

This study identifies distinct tau filament structures in FTLD-tau caused by the MAPT S305I mutation, revealing a unique 4-layer architecture and potential RNA-like polyanion binding.

This paper designs de novo proteins to modify nanopore complexes, creating customized structural and functional properties for enhanced sequencing applications.

The paper demonstrates the feasibility of engineering a transmembrane histidine kinase with a de novo metal-binding sensor domain that transmits binding information.

The paper develops a method to determine sequence-dependent propensities for membrane protein insertion states using glycosylation patterns and UMAP analysis.