The Emergence of Novel Versus Known Three-Dimensional Structures from Random Sequences.
Rose Yang, Hyunjun Yang, Anton Davydenko, Zack Mawaldi, Rian C. Kormos, Dru Myerscough, Yibing Wu, William F. DeGrado
This study shows that random sequences repeated in tandem are more likely to fold into stable structures than fully random sequences, with some structures being novel and experimentally confirmed.
Proceedings of the National Academy of Sciences · Jun 29, 2026Peer-reviewedBiophysics