A tumor metabolism-angiogenesis-immune axis governs immunotherapy responses
Inna S. Serganova, Giorgia Colombo, Francesco Ballesio, Jee Hye Kang, Triantafyllia R. Karakousi, Tullio Esposito, Ellen Ackerstaff, Anthony Santella, Ronald G. Blasberg, Nagavarakishore Pillarsetty, Ashley Schreier, Eleni Andreopoulou, Sandra Demaria, Amanda W. Lund, Pier Federico Gherardini, Roberta Zappasodi
This study shows that reducing tumor glycolysis improves immunotherapy responses by normalizing the tumor microenvironment and enhancing immune cell activity.
bioRxiv · Feb 24, 2026 · PreprintImmunology