Amanda W. Lund

The paper shows cancer cells adapt along a proliferation-robustness axis in response to TME components, leading to pro-tumor phenotypes.

This study shows that lymphatic remodeling in skin and lymph nodes constrains germinal center size and function to optimize protective antibody responses during viral infection.

The paper identifies progranulin as a mediator of immune suppressive niches in brain metastasis using cross-species spatial transcriptomics and functional analyses.

This study shows that lymph nodes actively drive melanoma evolution and immune evasion, linking regional metastasis to poor patient outcomes.

The paper identifies a lymphatic circuit that sustains stem-like CD8+ T cells by recycling tumor-experienced effector T cells, enhancing immune surveillance and ICB response.

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

This study shows that reducing tumor glycolysis improves immunotherapy responses by normalizing the tumor microenvironment and enhancing immune cell activity.

This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.

This study shows that IFNγ suppresses lymphatic vessel growth and metastasis by altering metabolism and immune function in melanoma.

This study identifies immune niches in NF1 mutant melanoma that promote immune evasion and shows EGFR inhibition can restore immune responses.

This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.

This study shows that deleting SHP1 and SHP2 in T cells increases CD4+ T cell activation-induced cell death and reduces antitumor responses, with SHP2 loss enhancing anti-PD-1 therapy.

This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.