Author

Yuchen Cheng

Washington University in St. LouisORCID 0000-0002-5903-9773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3

Frequent Co-Authors

Andrew RuttenbergiD· 2 shared Benjamin K. JohnsoniD· 2 shared Benpeng MiaoiD· 2 shared Chad TomlinsoniD· 2 shared Daofeng LiiD· 2 shared Edward A. BelteriD· 2 shared Elvisa MehinoviciD· 2 shared Hui SheniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Andrew RuttenbergORCID

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3 papers

Recent·Most cited

Leveraging Human Pangenome for Improved Somatic Variant Detection

Qichen Fu, Zilan Xin, Benpeng Miao, Wenjin Zhang, Nahyun Kong, Zitian Tang, Andrew Ruttenberg, Derek Albracht, Edward A. Belter, John E. Garza, Chad Tomlinson, Elvisa Mehinovic, Jiawei Shen, Xiaoyu Zhuo, Shihua Dong, , Ting Wang

This study shows that using graph-based pangenomes and inferred donor-specific assemblies improves somatic variant detection compared to GRCh38.

bioRxiv · Jan 5, 2026 · PreprintGenomics

A Pangenomic Method for Establishing a Somatic Variant Detection Resource in HapMap Mixtures

Nahyun Kong, Zitian Tang, Andrew Ruttenberg, Juan F Macias-Velasco, Zefan Li, Wenjin Zhang, Benpeng Miao, Zilan Xin, Qichen Fu, Haeorum Park, Xiaoyu Zhuo, Elvisa Mehinovic, Edward A. Belter, Chad Tomlinson, John E. Garza, , Sheng Chih Jin

The paper develops a pangenomic method to create a benchmark resource for somatic variant detection using HapMap mixtures, identifying millions of variants across different genomic regions.

bioRxiv · Sep 29, 2025 · PreprintGenomics

Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Gannon A. McDonough, Yuchen Cheng, Katherine S. Morillo, Ryan N. Doan, Zinan Zhou, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian Stephen Appleby, Christopher A. Walsh, Jiri Safar, August Yue Huang, Michael B. Miller

This study investigates whether somatic mutations in PRNP contribute to sporadic Creutzfeldt-Jakob Disease (sCJD) by sequencing PRNP in 205 sCJD cases and 170 controls, finding no evidence of pathogenic somatic variants.

Acta Neuropathologica · Jul 24, 2024Peer-reviewedGenetics