Katherine S. Morillo

COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age

This study identifies SET1/COMPASS-mediated de novo transcription as a mechanism accelerating forgetting with age in C. elegans and humans.

Single-Nucleus Neuronal Transcriptional Profiling of Male C. elegans Uncovers Regulators of Sex-Specific and Sex-Shared Behaviors

The paper profiles single-nucleus RNA sequencing data from male and hermaphrodite C. elegans neurons to identify sex-specific and sex-shared transcriptional regulators of behavior.

Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

This study investigates whether somatic mutations in PRNP contribute to sporadic Creutzfeldt-Jakob Disease (sCJD) by sequencing PRNP in 205 sCJD cases and 170 controls, finding no evidence of pathogenic somatic variants.

The Neuron-specific IIS/FOXO Transcriptome in Aged Animals Reveals Regulatory Mechanisms of Neuronal and Cognitive Aging

This study investigates the IIS/FOXO pathway's role in cognitive aging using C. elegans, finding that daf-2 mutants exhibit distinct transcriptomic changes that enhance neuronal resilience.

Somatic mosaicism in amyotrophic lateral sclerosis and frontotemporal dementia identifies focal mutations associated with widespread degeneration

The paper identifies rare somatic mutations in sporadic ALS and FTD cases, suggesting they contribute to disease and widespread neurodegeneration.

High-Quality Nuclei Isolation from Postmortem Human Heart Muscle Tissues for Single-Cell Studies

The paper describes a method for isolating high-quality single nuclei from postmortem human heart tissue for DNA and RNA analysis, including quality control measures.