Jaap M. J. den Toonder

This paper introduces a breast duct-on-chip model to simulate invasive ductal carcinoma and test chemotherapies, finding that Paclitaxel inhibits invasion in 30% of tests and reveals flow-like cancer cell migration.

This study examines how channel geometry and flow conditions affect endothelial cell orientation and morphology in vessel-on-chip models, showing that tubular geometry and pulsatile flow enhance circumferential alignment.