Carlijn V. C. Bouten

This study shows that the PLN R14del mutation increases nuclear susceptibility to mechanical stress in cardiomyopathy, linking nuclear dysfunction to disease variability.

This study evaluates the functional performance of electrospun tissue-engineered heart valve scaffolds across different geometries under aortic conditions, finding consistent kinematics and no systematic effect of geometry on flow or pressure.

This study identifies a non-canonical role for Jagged1 in regulating mechanosensitive kinase activity in endothelial cells under mechanical stress.

The paper identifies Myo1c as a factor interacting with Jag1 in endothelial cells, showing its role in Jag1 trafficking under shear stress.

This study shows that substrate stiffness affects fibroblast phenotype, contractility, and migration independently of TGF-β stimulation during wound healing.

This study examines how channel geometry and flow conditions affect endothelial cell orientation and morphology in vessel-on-chip models, showing that tubular geometry and pulsatile flow enhance circumferential alignment.

This paper develops a scalable synthetic communication platform for mammalian cells using orthogonal receptors and coiled-coil peptides to enable logic gate computations in cell consortia.