Wenting Zhao

The paper uses single-nuclei RNA sequencing to analyze intracranial thrombi, identifying distinct cell populations and transcriptional changes, and inferring ligand-receptor interactions relevant to stroke.

This study examines the spatiotemporal myeloid response to chemotherapy in glioblastoma using multiple models, showing chemotherapy-induced genotoxic stress and inflammatory remodeling in myeloid cells.

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

The paper introduces consensus scHPF, a method to identify robust gene signatures from scRNA-seq data, and applies it to discover cell type-specific drug responses in glioma.

The paper identifies four molecularly distinct glioblastoma subtypes using single-cell protein-activity analysis and shows drug sensitivity is state-dependent.