Angeliki Mela

This study examines the spatiotemporal myeloid response to chemotherapy in glioblastoma using multiple models, showing chemotherapy-induced genotoxic stress and inflammatory remodeling in myeloid cells.

This study shows that IDH1-mutant glioma cells are more sensitive to cysteine-methionine deprivation and ferroptosis inducers, and that IDH inhibitors enhance this sensitivity.

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

This study shows that PDGF-BB overexpression in p53 null OPCs increases H3K27me3 and promotes proliferation by altering transcription.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

This study tracks glioma progression in mice, showing decreased neuronal synchrony, disrupted neurovascular coupling, and seizure-related hypoxia in infiltrated cortex.

The paper introduces metaVIPER, an algorithm to assess protein activity in orphan tissues and single cells by integrating multiple non-tissue-matched interactomes, improving reproducibility of protein-activity signatures.