Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations
David Bautista, Joseph F. Carr, Cassidy R. Whitehead, Brian Kostoch, Angela M. Mitchell
This paper shows that loss of DNA mismatch repair genes in E. coli and Salmonella increases antibiotic resistance independently of secondary mutations through increased homoeologous recombination and cell lysis.
PLoS Genetics · Feb 20, 2026Peer-reviewedMicrobiology