Structural insights into human excitatory amino acid transporter EAAT2
T. Kato, Tsukasa Kusakizako, Chunhuan Jin, Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki
This study reports cryo-EM structures of human EAAT2 in substrate-free and inhibitor-bound states, revealing structural features and the mechanism of selective inhibition.
bioRxiv · Nov 3, 2021 · PreprintMolecular Biology