Tsukasa Kusakizako

This study develops a potent B0AT1 inhibitor effective in a PKU mouse model by targeting an allosteric site.

The paper shows MT1, a Gi-coupled receptor, can also couple to Gs proteins, activates the Gs/cAMP pathway under long-term melatonin exposure, and presents the first solved structure of a Gi-coupled receptor-Gs complex.

This study reports cryo-EM structures of human EAAT2 in substrate-free and inhibitor-bound states, revealing structural features and the mechanism of selective inhibition.

The paper presents cryo-EM structures of CALHM channels from different species, revealing their ATP conduction and oligomerization mechanisms.

The paper presents the cryo-EM structure of the human LRRC8A protein, revealing its trimer-of-dimers assembly and structural features relevant to its function as a volume-regulated anion channel.