Structural insights into G protein activation by D1 dopamine receptor
Xiao Teng, Sijia Chen, Qing Wang, Zhao Chen, Xiaoying Wang, Niu Huang, Sanduo Zheng
The paper presents cryo-EM structures of D1 dopamine receptor-Gs complexes in different nucleotide states, revealing conformational changes and a sequence motif that determines G protein selectivity.
Science Advances · Jun 10, 2022Peer-reviewedMolecular Biology