Niu Huang

Do-it-yourself de novo antibody sequencing workflow that achieves complete accuracy of the variable regions

This paper describes a workflow for accurate de novo sequencing of antibody variable regions using mass spectrometry and open-source tools, achieving 100% accuracy in distinguishing leucine and isoleucine.

Structural insights into G protein activation by D1 dopamine receptor

The paper presents cryo-EM structures of D1 dopamine receptor-Gs complexes in different nucleotide states, revealing conformational changes and a sequence motif that determines G protein selectivity.