Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions
Wenxin Hu, Amit Kumar, Shijiao Qi, Teresa Sadras, Joshua M. L. Casan, David K. G. Ma, Lauren M. Brown, Michelle Haber, Ilia Voskoboinik, Joseph A. Trapani, Paul G. Ekert, Mohamed Fareh
This study designs CRISPR-Cas13b crRNAs with single-base precision to silence oncogenic gene fusions, enhancing targeting efficacy and selectivity.
bioRxiv · Jun 22, 2022 · PreprintMolecular Biology