Author

Ilia Voskoboinik

The University of MelbourneORCID 0000-0002-6410-009XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:CRISPR screen· 3 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Joseph A. TrapaniiD· 4 shared Mohamed FarehiD· 3 shared Wenxin HuiD· 3 shared Adrian W. HodeliD· 2 shared Carolyn ShembreyiD· 2 shared Joshua M. L. CasaniD· 2 shared Lauren M. BrowniD· 2 shared Paul G. EkertiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersMolecular Biology

Joseph A. TrapaniORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phase-Separated RNA Condensates Govern Cas13 Target Accessibility and Cleavage

Gurjeet Jagjeet Singh, Wenxin Hu, Carolyn Shembrey, Adrian W. Hodel, Ilia Voskoboinik, Paul McMillan, Joseph A. Trapani, Mohamed Fareh

This study shows that Cas13 forms phase-separated RNA condensates to enhance target RNA accessibility and cleavage efficiency in both bacterial and mammalian cells.

bioRxiv · May 13, 2026 · PreprintMolecular Biology

Systematic silencing of oncogenic fusion transcripts with ultra-precise CRISPR-Cas13b

Wenxin Hu, Honglin Chen, Joshua M. L. Casan, Carolyn Shembrey, Steven He, Lauren M. Brown, Timothy P. Hughes, Deborah L. White, Antoine de Weck, Ilia Voskoboinik, Joseph A. Trapani, Paul G. Ekert, Teresa Sadras, Mohamed Fareh

This paper introduces CRISPR-PspCas13b as a method to systematically silence oncogenic fusion transcripts, showing effectiveness against drug-resistant cancer drivers.

bioRxiv · Feb 10, 2025 · PreprintMolecular Biology

Acidic pH attenuates immune killing through inactivation of perforin

Adrian W. Hodel, Jesse A. Rudd-Schmidt, Tahereh Noori, Christopher J. Lupton, Veronica C T Cheuk, Joseph A. Trapani, Bart W. Hoogenboom, Ilia Voskoboinik

This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.

EMBO Reports · Jan 9, 2025Peer-reviewedImmunology

Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions

Wenxin Hu, Amit Kumar, Shijiao Qi, Teresa Sadras, Joshua M. L. Casan, David K. G. Ma, Lauren M. Brown, Michelle Haber, Ilia Voskoboinik, Joseph A. Trapani, Paul G. Ekert, Mohamed Fareh

This study designs CRISPR-Cas13b crRNAs with single-base precision to silence oncogenic gene fusions, enhancing targeting efficacy and selectivity.

bioRxiv · Jun 22, 2022 · PreprintMolecular Biology