Latrophilin-2 mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosis
Keiichiro Tanaka, Minghao Chen, Divyesh Joshi, Manasa V.L. Chanduri, Hanming Zhang, Carlos F Fernandez-Hernando, Yoo-Min Koh, Martin Alexander Schwartz
This study shows LPHN2 is essential for flow-induced Notch activation to suppress inflammation and atherosclerosis in endothelial cells.
bioRxiv · Jul 1, 2025 · PreprintMolecular Biology