Author

Minghao Chen

Yale UniversityORCID 0000-0001-7719-3961Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Minghao Chen1 paper · East China University of Science and Technology

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Keiichiro TanakaiD· 3 shared Martin Alexander SchwartziD· 3 shared Andrew E. PrendergastiD· 2 shared Divyesh JoshiiD· 2 shared Manasa V.L. ChanduriiD· 2 shared Yoo-Min KohiD· 2 shared Abhishek KumariD· 1 shared Ali R. NasiriiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Keiichiro TanakaORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 1, 2025

Latrophilin-2 mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosis

Keiichiro Tanaka, Minghao Chen, Divyesh Joshi…·Martin Alexander Schwartz

This study shows LPHN2 is essential for flow-induced Notch activation to suppress inflammation and atherosclerosis in endothelial cells.

DOI 10.1101/2025.07.01.662676

mousebulk RNA-seq

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Cell BiologybioRxivPreprintJun 30, 2025

Latrophilin-2 Orchestrates Endothelial Flow-Mediated Smad1/5 Activation via Endoglin and Shank3

Keiichiro Tanaka, Manasa V.L. Chanduri, Hyojin Park…·Martin Alexander Schwartz

This paper identifies Latrophilin-2 as a mediator of flow-induced Smad1/5 activation in endothelial cells through interactions with Endoglin and Shank3, independent of G-proteins.

1 citation

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Molecular BiologyThe EMBO JournalPeer-reviewedJun 17, 2024

Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions

Keiichiro Tanaka, Minghao Chen, Andrew E. Prendergast…·Martin Alexander Schwartz

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.

27 citationstop 5%

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