Divyesh Joshi

This study shows LPHN2 is essential for flow-induced Notch activation to suppress inflammation and atherosclerosis in endothelial cells.

This paper shows Rudhira regulates TGFβ signaling and microtubule stability during mouse vascular development through both direct and transcriptional mechanisms.

This study identifies PRC2 as a driver of atherosclerosis by suppressing Klf2/4, and shows that inhibiting PRC2 with tazemetostat reduces plaque progression and improves stability.

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.

This study shows VEGF inhibits arterial specification in capillaries by suppressing Sox17, preventing premature arterialization driven by shear stress.

This study identifies Rudhira's role in cytoskeletal crosstalk during endothelial cell migration and angiogenesis, showing its necessity for microtubule-IF crosslinking and cell movement.