Richard S. Lewis

Structural rearrangements underlying the activation of STIM1 by ER calcium depletion

This study investigates how ER calcium depletion triggers structural changes in STIM1 that enable CAD release and Orai1 channel activation through single-molecule FRET experiments.

Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

This paper describes an optical method to study CRAC channel gating using HaloTag and a Ca2+-sensitive dye, overcoming limitations of traditional electrophysiology.

Multiple weak brakes act in concert to regulate STIM1 and control store-operated calcium entry

This study identifies four weak restraints that regulate STIM1 activity to control store-operated calcium entry, showing their concerted action prevents spontaneous activity and enables reversible activation.