Ruoyi Qiu

This study investigates how ER calcium depletion triggers structural changes in STIM1 that enable CAD release and Orai1 channel activation through single-molecule FRET experiments.

This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.

This study identifies four weak restraints that regulate STIM1 activity to control store-operated calcium entry, showing their concerted action prevents spontaneous activity and enables reversible activation.