Jonathan Mitchel

This paper shows segmentation errors in spatial transcriptomics data confound downstream analysis and proposes a method to mitigate their impact.

The paper introduces scJLIM, a cluster-free method for single-cell colocalization testing, improving power to link GWAS loci with gene expression changes in specific cell types.

This paper introduces scITD, a method to identify multicellular gene expression patterns that distinguish disease individuals, showing its application in SLE and COVID-19 datasets.

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.