Xinyuan Wang

Physiological fatty acid uptake reveals spatial and systemic constraints on nutrient accessibility in vivo

The paper quantifies physiological fatty acid uptake in vivo and shows that nutrient accessibility differs from uptake capacity, shaped by tissue architecture and systemic constraints.

NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease

NERINE tests gene network hypotheses with rare variant associations, identifying a subnetwork linked to Parkinson's disease.

Synthesis of Cyclopropene-Modified Fatty Acids Allows Single Cell Quantification of Uptake By Immune Cells

This study develops clickable fatty acids to quantify single-cell uptake by immune cells, finding polyunsaturated fatty acids are preferentially taken up by various immune cell types.

A single-cell genetic colocalization test improves power and resolves disease-mediating cell types

The paper introduces scJLIM, a cluster-free method for single-cell colocalization testing, improving power to link GWAS loci with gene expression changes in specific cell types.

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of alpha-synuclein inclusions

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.