Charles C.T. Hindmarch

PHELEX provides a searchable repository of RNA sequencing data for pulmonary hypertension, enabling analysis and cross-study comparisons to uncover molecular signatures.

This study examines how testosterone affects gene expression in the paraventricular nucleus of male and female spontaneously hypertensive rats, finding significant changes in gene regulation linked to hormone signaling and blood pressure.

This paper shows that NDUFS2 in mitochondrial Complex I is critical for oxygen responsiveness in human DASMCs, affecting calcium, cell shortening, and mROS without altering respiration.

This study identifies mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease, revealing nDNA-mtDNA interactions that influence metabolic pathways and insulin resistance.

Confidence is a web app that performs differential gene expression analysis, gene scoring, and enrichment analysis to prioritize genes for further investigation.