This paper develops biocatalytic methods for asymmetric radical dearomatization of electrophilic arenes, achieving stereoselective transformations of challenging substrates.

bioRxiv · Nov 9, 2026 · PreprintBiochemistry

A binuclear copper enzyme platform for enantioconvergent radical (pseudo)halogenation

Xiao‐Wang Chen, Oluwatosin Maryam Adeyemo, Heyu Chen, Hongda Chen, Ngoc Nguyen, Joseph Palazzo, Liupeng Zhao, Ken Lin, Binh Khanh Mai, Peng Liu, Shiliang Tian, Yang Yang

This study reprograms binuclear copper enzymes to catalyze enantioselective radical (pseudo)halogenation reactions, demonstrating superior activity and selectivity compared to nonheme Fe enzymes.

bioRxiv · Sep 22, 2026 · PreprintBiochemistry

Influence of Primary Coordination Sphere on Anion Rebound Selectivity in Nonheme Fe Enzyme-Catalyzed C(sp3)-H Functionalization: A Comparative Experimental and Computational Study of EgtB and ACCO

Liu-Peng Zhao, Rui Guo, Binh Khanh Mai, Heyu Chen, Peng Liu, Yang Yang

This paper compares experimental and computational studies of EgtB and ACCO to understand how their coordination sphere affects anion rebound selectivity in nonheme Fe enzyme-catalyzed C(sp3)-H functionalization.

Journal of the American Chemical Society · Jul 17, 2026Peer-reviewedBiochemistry