Yang Yang

This paper develops biocatalytic methods for asymmetric radical dearomatization of electrophilic arenes, achieving stereoselective transformations of challenging substrates.

This study uses EPR and ENDOR spectroscopy along with DFT to show how protein scaffolds alter the electronic structure of a ketyl radical intermediate in TPP-dependent radical biocatalysis, affecting enzyme reactivity.

This study identifies new photobiocatalytic C-C couplings by combining PLP enzymes with photocatalysts, enabling the synthesis of non-canonical amino acids through directed evolution.

This paper develops engineered PLP-dependent biocatalysts for stereodivergent synthesis of non-canonical amino acids with complex stereochemical arrays, achieving high stereoselectivity and yield.

This paper introduces a photobiocatalytic three-component radical coupling method that enables the stereoselective assembly of congested stereocenters using evolved biocatalysts and photosensitizers.

This study reprograms binuclear copper enzymes to catalyze enantioselective radical (pseudo)halogenation reactions, demonstrating superior activity and selectivity compared to nonheme Fe enzymes.

This study identifies features contributing to catalytic efficiency in a de novo enzyme through computational design and directed evolution, showing how stability and dynamics interplay in enzyme optimization.

This paper develops a photometallobiocatalytic method for enantioselective C-C cross-coupling of pyridotriazoles and alkyltrifluoroborate salts using a photosensitizer and engineered protoglobin.

This paper compares experimental and computational studies of EgtB and ACCO to understand how their coordination sphere affects anion rebound selectivity in nonheme Fe enzyme-catalyzed C(sp3)-H functionalization.

SynFit improves protein fitness prediction by learning shared and property-specific sequence representations, outperforming existing methods in multi-objective optimization.

EnzyGen2 co-designs protein sequences and structures with ligand-guided functionality, outperforming existing methods in in silico benchmarks and generating active enzymes with high novelty.

This paper develops a biocatalytic method using engineered PLP enzymes to selectively synthesize L- and D-amino acids from alkyl radicals.

This paper designs and evolves de novo helical bundle proteins to catalyze enantioselective Ge-H insertion, showing improved efficiency and selectivity through computational analysis and directed evolution.