Generative machine learning of ADAR substrates for precise and efficient RNA editing
Yue Jiang, Lina R Bagepalli, Bora S. Banjanin, Yiannis A. Savva, Yingxin Cao, Lan Guo, Adrian W. Briggs, Brian J. Booth, Ronald J. Hause
This paper develops DeepREAD, a generative model for designing ADAR guide RNAs to enable efficient and specific RNA editing for therapeutic applications.
bioRxiv · Sep 27, 2024 · PreprintBioengineering