Author

Lina R Bagepalli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:diffusion model· 1 Organism:mouse· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Brian J. BoothiD· 3 shared Yiannis A. SavvaiD· 3 shared Yingxin CaoiD· 3 shared Yue JiangiD· 3 shared Adrian W. BriggsiD· 2 shared Lucia R. ShumakeriD· 2 shared Ronald J. HauseiD· 2 shared Stephen M BurleighiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBioengineering

Brian J. BoothORCID

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Author profile →

3 papers

Recent·Most cited

Rett syndrome lifespan extension in mice via AI-guided ADAR editing

Yiannis A. Savva, Brian J. Booth, Lucia R. Shumaker, Rachael D. Fasnacht, Stephen M Burleigh, Yue Jiang, Yingxin Cao, Brian Johnson, Lina R Bagepalli, Forrest Golic, Nicole Enger, Rachel Feiring, Andrew Sadowski, Scott Rich, Anupama Lakshmanan, , Alison VanSchoiack

This paper uses AI-guided ADAR editing to correct a nonsense mutation in mice, improving Rett syndrome symptoms and extending lifespan.

bioRxiv · Jun 28, 2026 · PreprintNeuroscience

Helix: a structure-aware deep learning model for accurate prediction of A-to-I RNA editing by endogenous ADARs

Yingxin Cao, Lina R Bagepalli, Yiannis A. Savva, Sierra M. Collins, Kristofor Adams, Alexander J. Letizia, Joanne Boysen, Aydin Abiar, Samantha R. Edwards, Lillian Bussema, Stephen M Burleigh, Lucia R. Shumaker, Ronald J. Hause, Brian J. Booth, Yue Jiang

Helix predicts A-to-I RNA editing by ADARs with high accuracy using a structure-aware transformer model, enabling efficient gRNA design for therapeutic applications.

bioRxiv · Dec 20, 2025 · PreprintBioengineering

Generative machine learning of ADAR substrates for precise and efficient RNA editing

Yue Jiang, Lina R Bagepalli, Bora S. Banjanin, Yiannis A. Savva, Yingxin Cao, Lan Guo, Adrian W. Briggs, Brian J. Booth, Ronald J. Hause

This paper develops DeepREAD, a generative model for designing ADAR guide RNAs to enable efficient and specific RNA editing for therapeutic applications.

bioRxiv · Sep 27, 2024 · PreprintBioengineering