Brian J. Booth

This paper uses AI-guided ADAR editing to correct a nonsense mutation in mice, improving Rett syndrome symptoms and extending lifespan.

Helix predicts A-to-I RNA editing by ADARs with high accuracy using a structure-aware transformer model, enabling efficient gRNA design for therapeutic applications.

This paper develops DeepREAD, a generative model for designing ADAR guide RNAs to enable efficient and specific RNA editing for therapeutic applications.