Advances in protein function prediction from the fifth CAFA challenge
M. Clara De Paolis Kaluza, Rashika Ramola, Parnal Joshi, Damiano Piovesan, Walter Reade, Sandra E. Orchard, Maria Jesus Martin, Alexandr Ignatchenko, Burkhard Rost, Christine Anne Orengo, Marc Robinson‐Rechavi, Dannie Durand, Steven E. Brenner, Casey S. Greene, Sean David Mooney, , Predrag Radivojac A
This work analyzes CAFA5 submissions, showing improved accuracy in protein function prediction and highlights the role of protein language models and 3D structures in performance gains.
bioRxiv · Jun 10, 2026 · PreprintBioinformatics