Chromatin regulates genome-wide transcription factor binding affinities
Hannah K. Neikes, Rik G.H. Lindeboom, Cathrin Gräwe, Lieke A. Lamers, Marijke P. A. Baltissen, Pascal W.T.C. Jansen, Simon J. van Heeringen, Colin Logie, Sarah Amalia Teichmann, Michiel Vermeulen
The paper quantifies how chromatin context affects transcription factor binding affinities genome-wide and shows DNA accessibility is the main determinant.
bioRxiv · Apr 4, 2022 · PreprintGenomics