Author

Mengfan Lyu

University of Illinois Urbana-ChampaignORCID 0000-0002-6089-0135Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Beth M. StadtmuelleriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

1 paper

Recent·Most cited

Chimeric Immunoglobulin and human Immunoglobulin M structures provide insights on joining-chain independent assembly and function

Mengfan Lyu, Beth M. Stadtmueller

The paper reports cryo-EM structures of chimeric and human IgM, revealing structural insights into JC-free pIgM assembly and demonstrating antigen-targeting potential for disease prevention.

bioRxiv · Jul 9, 2025 · PreprintImmunology