This paper uses Mendelian randomization to investigate the causal relationship between branched chain amino acids (BCAAs) and type 2 diabetes, finding that BCAAs are biomarkers of diabetes and higher insulin rather than mediators.

medRxiv · May 23, 2023 · PreprintGenetic & Genomic Medicine

A 6-CpG Validated Methylation Risk Score Model for Metabolic Syndrome: The HyperGEN and GOLDN Studies

Bertha Hidalgo, Bré Minniefield, Amit Patki, Rikki M. Tanner, Minoo Bagheri, Hemant K. Tiwari, Donna K. Arnett, Marguerite R. Irvin

The paper develops a methylation risk score model for metabolic syndrome using data from two ethnic groups, showing its predictive power across populations.

PLoS ONE · Nov 15, 2021Peer-reviewedGenetics

Leveraging a founder population to identify novel rare-population genetic determinants of lipidome

May E. Montasser, Stella W. Aslibekyan, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amit Patki, Minoo Bagheri, Tobias Kind, Dinesh Kumar Barupal, Sili Fan, James A. Perry, Kathleen A. Ryan, Donna K. Arnett, Amber L. Beitelshees, Marguerite R. Irvin, Jeffrey R. O’Connell

The paper identifies novel genetic determinants of lipidome variation in a founder population, highlighting rare alleles associated with specific lipid species and replicating known common loci.

bioRxiv · May 21, 2021 · PreprintGenetics